Evidence map›Paper›PMID 40959686›Full record

ReviewPostepy psychiatrii neurologii2025

From "bad trips" to "transformative and potentially therapeutic trips": harnessing the potential of psychedelics - narrative review.

Nikolaos Statharakos, Elisavet Papadopoulou, Aaron J Alvares, Aikaterini Mara

Abstract readReview
In one paragraph

Review in Postepy psychiatrii neurologii, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nikolaos StatharakosGeneral Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.
Elisavet PapadopoulouGeneral Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.
Aaron J AlvaresSofia University "St Kliment Ohridski", Sofia, Bulgaria.
Aikaterini MaraGeneral Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Psychedelic substances are attracting attention for their therapeutic potential in mental health disorders. Emerging research suggests that even negative psychedelic experiences, or "bad trips," may hold therapeutic potential when managed in controlled settings. This narrative review explores the nature of "bad trips", their contributing factors, and their integration into therapeutic practices. Views: Data for this review were identified through systematic searches of PubMed, PsycINFO, and Scopus using keyword "bad trip", "psychedelic therapy" with the use of Boolean variable AND. Articles were selected based on their relevance, recency, and methodological rigor. Key studies were analyzed to extract findings on psychological mechanisms and therapeutic frameworks related to challenging psychedelic experiences. Bad trips frequently involve intense fear, anxiety, and unresolved traumas. Controlled therapeutic settings allow for these experiences to catalyze emotional processing, trauma resolution, and transformative insights. Historical and contemporary studies highlight long-term mental health improvements following the effective integration of such experiences. Ethical considerations, including informed consent and aftercare, are critical to mitigate risks and optimize outcomes. Conclusions: While distressing, bad trips may act as catalysts for psychological growth in therapeutic contexts with trained facilitators. Further research is needed to refine therapeutic protocols and elucidate the long-term effects of challenging psychedelic experiences, offering innovative approaches to mental health treatment.

Indexed as

bad trippsychedelic adverse reactionspsychedelic therapypsychopharmacology

Identifiers

PMID40959686
PMCPMC12435557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.