Evidence map›Paper›PMID 40959598›Full record

ArticleRSC medicinal chemistry2025

Olefinic side chain modification of fusidic acid enhances anti-MRSA activity and mitigates resistance development.

Wu-He Wu, Li-Juan Song, Kai-Yuan Bai, Fu-Huan Luo, Ya-Xin Li, Jing Luo, Xing-Fu Liu, Shang-Gao Liao, Jun-Li Ao, Guo-Bo Xu

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wu-He WuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Li-Juan SongState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Kai-Yuan BaiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Fu-Huan LuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Ya-Xin LiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Jing LuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Xing-Fu LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Shang-Gao LiaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Jun-Li AoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.
Guo-Bo XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University 6 Ankang Avenue, Guian New District 561113 Guizhou China aojl90@163.com xguobo@163.com.ORCID https://orcid.org/0000-0001-9121-4618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The escalating prevalence of antibiotic resistance underscores the urgent need for innovative antimicrobial agents. Fusidic acid (FA), a fungal-derived tetracyclic triterpene clinically employed against methicillin-resistant

Identifiers

PMID40959598
PMCPMC12435587

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.