Vascular Endothelial Protection Effects of

Li-Hsien Chen, Sheau-Chung Tang, Shu-Er Yang, Erl-Shyh Kao

Abstract read

In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li-Hsien ChenDepartment of Food Science, Tunghai University, Taichung 407224, Taiwan.

Sheau-Chung TangDepartment of Nursing, National Taichung University of Science and Technology, Taichung 403027, Taiwan.

Shu-Er YangDepartment of Beauty Science and Graduate Institute of Beauty Science Technology, Chienkuo Technology University, Changhua 500020, Taiwan.

Erl-Shyh KaoDepartment of Beauty Science, National Taichung University of Science and Technology, Taichung 403027, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis caused by bacterial infection can also induce vascular endothelial damage through endotoxins secreted by bacteria such as lipopolysaccharides (LPS). The mechanism of LPS induce vascular endothelial damage is mainly through the release of pro-inflammatory factors and activation of matrix metalloproteinases (MMPs), then MMPs further cause the glycocalyx layer to damage endothelial cells and finally lead to hyperosmolar vascular abnormalities and eventually microcirculatory disorders in general clinical practice, and are used in clinical treatment to prevent the release of pro-inflammatory factors. However, the immunosuppressive effect of high-dose dexamethasone is unpredictable before pathogens are cleared.

Indexed as

CurcumaEndothelium, VascularPlant ExtractsSepsisAnimalsDisease Models, AnimalHumansLipopolysaccharidesMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Plant RootsRatsRats, Sprague-DawleySesquiterpenesSignal Transductionbeta-elemeneLipopolysaccharidesMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, ratMmp9 protein, ratPlant ExtractsSesquiterpenesTlr4 protein, ratToll-Like Receptor 4acute vascular damageCurcuma wenyujinlipopolysaccharidesmatrix metalloproteinase

Identifiers

PMID40959576

DOI10.7150/ijms.112103

PMCPMC12434830

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.