Evidence map›Paper›PMID 40959560›Full record

ArticleInternational journal of medical sciences2025

C-C chemokine receptor type 5 activation stimulates adipocyte differentiation through ERK-dependent pathway.

Luen-Kui Chen, Chien-Wei Chen, Shao-Yun Wu, Shui-Yu Liu, Liang-Yi Wu, Chi-Jen Chang, Leticia B Sy, Chi-Chang Juan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luen-Kui ChenInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Chien-Wei ChenDepartment of Physical Education, Health, and Recreation, Teachers College, National Chiayi University, Chiayi 621302, Taiwan.
Shao-Yun WuInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Shui-Yu LiuInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Liang-Yi WuDepartment of Bioscience Technology, College of Science, Chung-Yuan Christian University, Chung Li 32023, Taiwan.
Chi-Jen ChangDivision of Pediatric Surgery, Department of Surgery, Shin-Kong Wu Ho-Su Hospital, Taipei, Taiwan.
Leticia B SySchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Chi-Chang JuanInstitute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is associated with low-grade chronic inflammation, and research has shown that RANTES and CCR5 mRNA levels are notably higher in the visceral adipose tissue of obese individuals compared to lean controls. However, the precise role of CCR5 activation in obesity development is still unclear. This study aims to explore the impact of CCR5 activation on adipogenesis and the underlying regulatory mechanisms. The study used 3T3-F442A preadipocytes and primary preadipocytes from wild-type (WT) and CCR5 knockout (CCR5

Indexed as

AdipocytesAdipogenesisObesityReceptors, CCR5AnimalsCell DifferentiationChemokine CCL5Diet, High-FatHumansMaleMAP Kinase Signaling SystemMaravirocMiceMice, Inbred C57BLMice, KnockoutCcl5 protein, mouseCCR5 protein, mouseChemokine CCL5MaravirocReceptors, CCR5adipocyteCCR5differentiationmetabolic syndromeobesityRANTES

Identifiers

PMID40959560
PMCPMC12434692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.