ArticleFrontiers in neurology2025
Relationship between cortical activation and sleep quality in cerebral small vessel disease patients: a functional near-infrared spectroscopy (fNIRS) study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sleep disturbance is common in patients with cerebral small vessel disease (CSVD). The impact of insomnia on cortical activation in CSVD patients and its association with sleep quality remains unclear. Our study used functional near-infrared pectroscopy (fNIRS) to investigate differences in cortex activation in CSVD patients with sleep disturbance (CSVD + S) and CSVD patients without sleep disturbance (CSVD - S) during the verbal fluency task (VFT), and further explored its relationship with sleep quality. Methods: 59 CSVD + S and 69 CSVD - S matched for age, gender, and educational level were recruited. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). fNIRS was used to assess frontotemporal activation in CSVD patients during the VFT. Results: The prevalence of sleep disturbance in CSVD patients was 46.01%. Compared to CSVD - S, CSVD + S exhibited lower cortex activation in the bilateral medial prefrontal cortex (mPFC) and dorsolateral prefrontal cortex (DLPFC) (false discovery rate corrected Conclusion: Our study used fNIRS to demonstrate that CSVD patients with sleep disturbance showed poorer prefrontal cortex activation during the VFT, which is associated with poorer sleep quality.
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