Evidence map›Paper›PMID 40959490›Full record

ReviewFrontiers in cardiovascular medicine2025

Ultrasound-targeted microbubble destruction: a prospective strategy for treating cardiovascular disease.

Shuting Yang, Rong Zhang, Huali Zhang, Yongping Lu

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuting Yang *Department of Ultrasound, The Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, Kunming, China.
Rong Zhang *Department of Ultrasound, The Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, Kunming, China.
Huali ZhangDepartment of Ultrasound, The Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, Kunming, China.
Yongping LuDepartment of Ultrasound, The Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In China, the healthcare burden of cardiovascular diseases (CVDs) will continue to rise due to the pressure of the aging population, which has posed higher demands for CVDs prevention and treatment. Ultrasound-targeted microbubble destruction (UTMD) is an ultrasound-triggered drug delivery technique based on microbubbles. This technique utilizes the principles of cavitation and sonoporation to enhance the delivery of genes or drugs to target tissue. This review article will provide an overview of studies using UTMD to treat CVDs over the last decade. In light of these studies, we underscore the potential therapeutic targets and delineate the practical substances that can be loaded onto microbubbles. Additionally, a discussion is provided regarding the limitations and prospects of this field.

Indexed as

atherosclerosisblood-brain barrier (BBB)cardiovascular diseasemicrobubbleultrasoundultrasound targeted microbubble destruction (UTMD)

Identifiers

PMID40959490
PMCPMC12434411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.