Evidence map›Paper›PMID 40959483›Full record

ReviewNanotheranostics2025

Plant-Derived Natural Product-Based Nanoformulations for Healthcare Application.

Saloni Kakkar, Rajan K Jha, Deeksha Hattila, Abhishek Kumar Singh, Pradeep K Shukla, Shiv Pratap Singh Yadav, Avtar S Meena

Abstract readReview
In one paragraph

Review in Nanotheranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saloni KakkarCSIR-Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad, Telangana, India.
Rajan K JhaCSIR-Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad, Telangana, India.
Deeksha HattilaDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Abhishek Kumar SinghManipal Center for Biotherapeutics Research, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India.
Pradeep K ShuklaDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Shiv Pratap Singh YadavCSIR-Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad, Telangana, India.
Avtar S MeenaDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants produce numerous natural compounds developed into commercial products. These compounds offer medicinal benefits for treating diseases like diabetes, neurological disorders, malaria, and cancer. They also serve as hepatoprotective agents and immunomodulators. These natural products are secondary metabolites that plants produce for their defense and adaptation. Recently, numerous reports have highlighted the effectiveness of natural products in different diseases. However, comprehensive analysis of plant-based products currently used in the clinical setting for various human diseases is insufficient. This review provides extensive information about the application of natural plant products in both clinical and preclinical settings. It highlights their role in developing drugs for human diseases. Additionally, these plant products could serve as diagnostic tools for various diseases. Plant-derived natural products, integrated with advanced nanotechnology-based approaches, could enhance healthcare monitoring without compromising treatment efficacy. Nanotechnology techniques employing both diagnostics and therapeutics, known as nanotheranostics, utilize engineered biocompatible nanomaterials with potential prospects for healthcare management. Nanomaterials like polymeric nanoparticles and liposomes offer diagnostic value by enabling real-time imaging of disease progression and treatment response. Functionalized with contrast agents or dyes, they enhance MRI, CT, PET, and fluorescence imaging, improving diagnosis, patient stratification, and monitoring of drug delivery and efficacy. With the increasing demand for natural dietary supplements, this issue encompasses the identification of various plant-based natural products as potential nanotheranostics with promising potential for chronic disorders such as cancer, neurological pathologies, diabetes, and immunological issues. This review focuses on applications of nanotheranostics utilizing natural products in biomedical applications, outlining the current breakthroughs, supplemented with future potentialities.

Indexed as

Biological ProductsNanoparticlesPlantsTheranostic NanomedicineAnimalsHumansBiological ProductsCancerDiabetesHealthcareImmunomodulation.NanoparticlesNanotheranosticsNatural products

Identifiers

PMID40959483
PMCPMC12435207

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.