ArticleFrontiers in medicine2025
Expression of cyclooxygenase-2 and smooth muscle actin biomarkers in different subtypes of basal cell carcinoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Basal cell carcinoma (BCC) is the most common form of skin cancer, with diverse subtypes and UV radiation as a major risk factor. Key markers like COX-2 and smooth muscle actin (SMA) are linked to tumor invasion. This study investigates their expression to improve understanding of BCC progression and treatment. Materials and methods: This Results: The study evaluated clinical and histological characteristics of basal cell BCC in 51 patients (mean age 64.12 ± 11.45 years, 66.7% male). Nodular BCC was the most common subtype (19.6%). SMA expression was observed in 88.2% of cases and COX-2 in 21.6%. COX-2 expression significantly correlated with invasion depth ( Conclusion: COX-2 expression significantly correlated with tumor invasion depth and recurrence in BCC, highlighting its potential as a prognostic marker and therapeutic target, while SMA showed limited relevance to tumor behavior. Although excision margin size did not show a statistically significant correlation with recurrence (
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