Evidence map›Paper›PMID 40959405›Full record

ArticleTransgender health2025

Frequency, Timing, and Management of Erythrocytosis in Adolescents Receiving Gender-Affirming Testosterone Therapy-A Retrospective Study.

Ashleigh McLean, Monsurul Hoq, Ken C Pang, Michele O'Connell

Abstract read
In one paragraph

Article in Transgender health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashleigh McLeanDepartment of Endocrinology and Diabetes, The Royal Children's Hospital, Victoria, Australia.
Monsurul HoqClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Ken C PangClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Michele O'ConnellDepartment of Endocrinology and Diabetes, The Royal Children's Hospital, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythrocytosis is a well-described effect of testosterone therapy in adults, but less is known about this phenomenon in transgender and gender-diverse adolescents. To explore this further, we performed a retrospective study in 158 adolescents who received gender-affirming testosterone therapy from January 2007 to April 2020 at a pediatric gender service. Erythrocytosis (hematocrit [Hct] > 0.50 L/L) developed in 9.5% (15/158) of adolescents. Frequency increased with time; in the majority (67%, 10/15), erythrocytosis occurred in the second year of treatment. Overall, our findings indicate erythrocytosis occurs commonly in testosterone-treated transgender adolescents and support the need for regular ongoing monitoring of Hct.

Indexed as

adolescentserythrocytosistestosteronetransgender

Identifiers

PMID40959405
PMCPMC12434153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.