ArticleCureus2025
Thalamic Tuberculoma Masquerading as a High-Grade Glioma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial tuberculomas are rare granulomatous infections that can closely mimic high-grade gliomas on imaging, posing significant diagnostic challenges, particularly in non-endemic regions. We present a case of a 54-year-old immunocompetent male patient with a background of schizophrenia who presented with acute right-sided weakness, left facial droop, and slurred speech. Initial imaging revealed a large left thalamic mass with midline shift and uncal herniation, concerning for a high-grade glioma. Magnetic resonance imaging (MRI) findings demonstrated a heterogeneous thalamic lesion with extensive surrounding white matter changes, elevated choline peak, and decreased N-acetylaspartic acid (NAA) on magnetic resonance (MR) spectroscopy, further supporting the preliminary diagnosis of glioma. However, systemic imaging revealed mediastinal lymphadenopathy and hepatic lesions suggestive of a lymphoproliferative or infectious process. Stereotactic biopsy of the lesion revealed chronic necrotizing granulomatous inflammation without evidence of neoplasia. Although acid-fast bacilli culture and mycobacterial polymerase chain reaction (PCR) were pending, empirical antituberculous therapy was initiated based on histopathology findings. Subsequent follow-up imaging showed marked reduction and near-complete resolution of the lesion, confirming the diagnosis of intracranial tuberculoma. This case highlights the radiologic and clinical overlap between intracranial tuberculomas and high-grade gliomas. Despite advanced imaging modalities such as MR spectroscopy and perfusion studies, differentiation remains challenging. Biopsy remains the gold standard for definitive diagnosis. Awareness of atypical presentations and careful integration of clinical, radiologic, and epidemiologic data are critical to avoid misdiagnosis and unnecessary neurosurgical interventions. Early initiation of antituberculous therapy can lead to excellent clinical and radiologic outcomes, as illustrated in this case.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.