ArticleCureus2025
Merkel Cell Carcinoma With Lymph Node Metastasis: A Case Emphasizing Early Diagnosis and Multidisciplinary Management.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Merkel cell carcinoma (MCC) is a rare but exceptionally aggressive neuroendocrine skin cancer, characterized by low global incidence yet significant clinical impact due to its propensity for early metastasis. Regional lymph node metastases occur frequently, while distant metastases are present in a substantial proportion of patients. The rising incidence over recent decades is largely attributed to the aging global population, associated immunosenescence, and increased cumulative ultraviolet (UV) radiation exposure, particularly UVB radiation. MCC's medical significance lies in its rapid progression, high metastatic potential, and poor prognosis, with survival rates decreasing markedly from localized disease to cases with regional lymph node involvement. This underscores the need for prompt recognition and management to optimize patient outcomes. Key risk factors include advanced age, with an exponential increase in incidence after retirement age, immunosuppression, and chronic sun/UV exposure. Merkel cell polyomavirus has been identified as an important etiologic factor in the majority of cases. This case report describes an elderly female patient who presented with a rapidly growing, ulcerated cervical lesion that had progressed substantially over several months. The lesion was initially misdiagnosed and inadequately treated with minor excision without histopathological analysis. Subsequent rapid local recurrence, extensive regional lymph node involvement, and definitive diagnosis, confirmed by characteristic immunohistochemical staining patterns, highlight the critical need for high clinical suspicion and meticulous histopathological evaluation. Palliative radiotherapy provided measurable clinical benefit, including significant pain relief and notable tumor size reduction. This case exemplifies how deficiencies in initial management can dramatically alter disease trajectory in aggressive malignancies, transforming potentially curable early-stage disease into advanced locoregional involvement requiring palliative treatment with markedly reduced survival expectations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.