Evidence map›Paper›PMID 40959313›Full record

ReviewRSC advances2025

Exosome-driven biohybrid nanorobots: bridging nature and nanotechnology in biomedical innovation.

Subham Preetam, Smita Lata, Aditi, Jutishna Bora, Shailendra Thapliyal, Shalini Mehta, Seema Ramniwas, Ravi Deshwal, Sarvesh Rustagi, Nayan Talukdar and 1 more

Abstract readReview
In one paragraph

Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Subham PreetamDepartment of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST) Daegu 42988 South Korea.ORCID https://orcid.org/0000-0002-5992-4609
Smita LataAmity Institute of Biotechnology, Amity University Jharkhand Ranchi Jharkhand India smalik@rnc.amity.edu.
AditiAmity Institute of Biotechnology, Amity University Jharkhand Ranchi Jharkhand India smalik@rnc.amity.edu.
Jutishna BoraAmity Institute of Biotechnology, Amity University Jharkhand Ranchi Jharkhand India smalik@rnc.amity.edu.
Shailendra ThapliyalUttaranchal Institute of Technology, Uttaranchal University Dehradun-248007 India.ORCID https://orcid.org/0009-0002-6212-2057
Shalini MehtaRanchi Women's College, Ranchi University Jharkhand India.
Seema RamniwasMarwari University Research Center, Faculty of Sciences, Marwari University Rajkot Gujrat-360003 India.
Ravi DeshwalInstitute of Bioscience and Technology, Shri Ramswaroop Memorial University Lucknow- Deva Road Uttar Pradesh 225 003 India.
Sarvesh RustagiDepartment of Food Technology, School of Agriculture, Maya Devi University Dehradun Uttrakhand India.ORCID https://orcid.org/0000-0002-1247-1040
Nayan TalukdarProgram of Biotechnology, Faculty of Science, Assam Down Town University Guwahati India.
Sumira MalikAmity Institute of Biotechnology, Amity University Jharkhand Ranchi Jharkhand India smalik@rnc.amity.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosome- and extracellular vesicle (EV)-based biohybrid nanorobots represent a cutting-edge approach in nanomedicine, combining the natural targeting, immune tolerance, and molecular transport capabilities of EVs with the functional versatility of engineered nanomaterials. These hybrid systems can be designed for guided or autonomous navigation, enabling site-specific drug delivery with minimal cytotoxicity. Recent advances have integrated magnetic, photothermal, or drug-loaded components into EVs, transforming them into innovative nanoscale delivery systems. As naturally secreted vesicles from most cell types, EVs facilitate intercellular communication and are increasingly recognized for their clinical potential in treating conditions like Crohn's disease, type 1 diabetes, and COVID-19. Biohybrid EV nanorobots offer enhanced biodistribution, stability, and cellular uptake compared to traditional nanoparticles. Key design challenges include ensuring reproducibility, size control, and functional stability. This next-generation drug delivery platform holds promise for overcoming limitations of conventional systems while advancing targeted therapy and personalized medicine.

Identifiers

PMID40959313
PMCPMC12434686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.