Evidence map›Paper›PMID 40959244›Full record

ArticleACS medicinal chemistry letters2025

Terpene-Based Thiazole Hydrazines as Negative Allosteric Modulators of MRGPRX4: In Vitro Evaluation and Binding Site Analysis.

Saqlain Haider, Manal M Alhusban, Pankaj Pandey, Suresh Chandra V A R Annam, Robert B Laprairie, Amar G Chittiboyina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saqlain HaiderNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.ORCID https://orcid.org/0000-0002-1738-6945
Manal M AlhusbanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.
Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.ORCID https://orcid.org/0000-0001-9128-8254
Suresh Chandra V A R AnnamNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.ORCID https://orcid.org/0000-0002-2099-2989
Robert B LaprairieCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon Saskatchewan S7N 5E5, Canada.
Amar G ChittiboyinaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.ORCID https://orcid.org/0000-0002-7047-5373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human MAS-related G-protein-coupled receptors (MRGPRs) represent a promising therapeutic target for managing chronic itch and pain. Among them, MRGPRX4 is activated by bile acids in dorsal root ganglia (DRG) neurons and contributes to the cholestatic itch. Here, we report the design, synthesis, and in vitro evaluation of a focused library of functionalized terpene-based thiazole hydrazines targeting MRGPRX receptors. Functional assays identified two compounds,

Indexed as

allosteric modulatorbinding site analysischronic itchMRGPRX4pruritogensThiazole hydrazines

Identifiers

PMID40959244
PMCPMC12434541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.