ArticleACS medicinal chemistry letters2025
Synthesis and Evaluation of Diphenylpyrazine Cyclic Amine Derivatives as IP Receptor Agonists.
Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Design, Synthesis, and Evaluation of Diphenylpyrazinyl Amino Cycloalkoxy Acetic Acids as IP Receptor Agonists.ACS medicinal chemistry letters · 2026Article
- Structure-optimization and structure-activity relationship of diphenylpyrazinyl aminoalkoxyacetic acid derivatives: piperidine substitution and hydrophobic modification as key strategies for IP receptor agonists.Journal of computer-aided molecular design · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary arterial hypertension (PAH) is a severe, progressive condition with limited treatments. This study focuses on developing novel IP receptor agonists for PAH therapy. By modifying MRE-269, a highly selective IP receptor agonist, we designed and synthesized 2-cyclic amino-5,6-diphenylpyrazine derivatives. Systematic evaluation revealed that introducing a dimethyl group at the C3 position of the piperidine ring significantly improved antiaggregatory activity. The optimal compound
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