Evidence map›Paper›PMID 40959167›Full record

ArticleERJ open research2025

A randomised controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants Placebo

Amy C Plint, Anna Heath, Tremaine Rowe, Kristina I Vogel, Natasha Wills-Ibarra, Sharon O'Brien, Meredith L Borland, David W Johnson, Joseph J Zorc, Petros Pechlivanoglou and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Amy C PlintDepartment of Pediatrics and Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0003-1245-7174
Anna HeathThe Hospital for Sick Children, Toronto, Ontario, Canada.
Tremaine RoweChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Kristina I VogelChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Natasha Wills-IbarraChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Sharon O'BrienPerth Children's Hospital, University of Western Australia, Nedlands, Western Australia, Australia.
Meredith L BorlandPerth Children's Hospital, University of Western Australia, Nedlands, Western Australia, Australia.
David W JohnsonDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Joseph J ZorcDivision of Emergency Medicine, Children's Hospital of Philadelphia, Pennsylvania, USA.
Petros PechlivanoglouThe Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Suzanne SchuhHospital for Sick Children, Toronto, Ontario, Canada.
Medhawani RaoStarship Children's Hospital, Auckland, New Zealand.
Megan BonischStarship Children's Hospital, Auckland, New Zealand.
Simon S CraigDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Serge GouinLe Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Amit KocharEmergency Department, Women and Children's Hospital, Adelaide, South Australia, Australia.
Graham C ThompsonDepartments of Pediatrics and Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Chris LashEmergency Department, Middlemore (Kidz First) Hospital, Auckland, New Zealand.
Alexandra WallaceDepartment of Pediatrics, Waikato Hospital, Hamilton, New Zealand.
Andrew DixonStollery Children's Hospital, Edmonton, Alberta, Canada.
Scott SawyerHSC Children's Hospital, Winnipeg, Manitoba, Canada.
Gary JoubertChildren's Hospital London Health Sciences Centre, London, Ontario, Canada.
Ed OakleyDepartment of Emergency Medicine, Royal Children's Hospital Melbourne, Victoria, Australia.
Martin OffringaHospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Terry P KlassenDepartment of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Stuart R DalzielChildren's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bronchiolitis exerts a significant burden of illness on infants worldwide. National guidelines advise only supportive care. There is evidence that treating infants with bronchiolitis with a combination of inhaled epinephrine and dexamethasone may reduce hospital admissions. Objective: The aim of this study is to determine if infants with bronchiolitis treated with inhaled epinephrine (delivered by metered dose inhaler with spacer or nebuliser) in the emergency department and a 2-day course of oral dexamethasone have fewer hospitalisations compared to infants treated with placebo. Methods: The BIPED study (Bronchiolitis in Infants Placebo Conclusion: Given the burden of bronchiolitis, there is urgent need for a trial to confirm if combination therapy with epinephrine and dexamethasone is effective.

Identifiers

PMID40959167
PMCPMC12434484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.