Evidence map›Paper›PMID 40959139›Full record

ArticleFrontiers in cellular and infection microbiology2025

LysR-type transcriptional regulator

Jiansheng Lin, Chunyan Lin, Jingyang Zheng

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Regulatory relationships amongFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiansheng LinMicrobiology Laboratory, Quanzhou Women's and Children's Hospital, Quanzhou, China.
Chunyan LinThe Affiliated Women's and Children's Hospital of Huaqiao University, Quanzhou, China.
Jingyang ZhengThe Affiliated Women's and Children's Hospital of Huaqiao University, Quanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Antibiotic susceptibility testing was conducted by the plate agar dilution method. Site-directed mutagenesis was conducted using Mut Express II Fast Mutagenesis Kit V2. Kinetic assays were used to determine the hydrolysis of β-Lactam. The construction of bacterial knockout strains was carried out according to the principle of homologous recombination. The detection of the mRNA expression level of the gene was performed by Real-time Quantitative PCR (qPCR). Results: The minimum inhibitory concentrations (MICs) for Conclusion: Overall, CAR-2 is a novel subclass B3 MBL of the CAR family that exhibits catalytic activity against cefalothin, cefuroxime and cefotaxime. CARR represses the expression of

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesGene Expression Regulation, BacterialTranscription FactorsCefotaximeCefuroximeCephalothinDrug Resistance, BacterialMicrobial Sensitivity TestsMutagenesis, Site-DirectedAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCefotaximeCefuroximeCephalothinTranscription Factorsantibiotic resistanceblaCAR-2LysR-type transcriptional regulator CARRmetallo-β-lactamases (MBLs)P. diazotrophicus

Identifiers

PMID40959139
PMCPMC12434095

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.