ArticleFrontiers in immunology2025
A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Mechanistic roles and clinical applications of tertiary lymphoid structures in colorectal cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2026Review
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19 authors.
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Abstract
Background: Methods: Single-cell RNA sequencing data from GSE146771, GSE146771, GSE200997, GSE205506, and GSE231559, along with bulk RNA-seq data from the TCGA CRC cohort, were analyzed. Prognostic genes were identified using univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression, and subsequently used to construct TLS-related prognostic signatures. Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curve analysis were used to evaluate the predictive performance of the signature. Immune infiltration was assessed using the ESTIMATE and CIBERSORT algorithms. Histopathological evaluation of TLS was conducted in tissue sections from 200 CRC patients. Clinicopathological features were compared between the Results: TLS displayed distinct expression patterns within the CRC tumor microenvironment. A 10-gene prognostic model was developed based on LASSO regression analysis. Patients with BRAF Conclusion: TLS-related prognostic signatures serve as effective tools for predicting CRC outcomes. Moreover, intratumorally TLS may enhance the prognosis of patients with BRAF
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