Evidence map›Paper›PMID 40958973›Full record

ArticleGynecologic oncology reports2025

Development of immune radiotherapy with yttrium by targeting Frizzled homologue 10 (FZD10) in cervical cancer.

Yuki Okuma, Yuji Ikeda, Osamu Kobayashi, Saki Kamata, Erina Matsuda, Takahiro Nakajima, Keisuke Saito, Naoko Tomita, Yoko Nakanishi, Yosuke Harada and 5 more

Abstract read
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuki OkumaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Yuji IkedaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Osamu KobayashiDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Saki KamataDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Erina MatsudaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Takahiro NakajimaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Keisuke SaitoDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Naoko TomitaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Yoko NakanishiDepartment of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Yosuke HaradaOncoTherapy Science Inc., Kawasaki, Kanagawa 210-0005, Japan.
Suyoun ChungOncoTherapy Science Inc., Kawasaki, Kanagawa 210-0005, Japan.
Jae-Hyun ParkOncoTherapy Science Inc., Kawasaki, Kanagawa 210-0005, Japan.
Shinobu MasudaDepartment of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.
Yusuke NakamuraNational Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan.
Kei KawanaDepartment of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku Tokyo 173-8610, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Radioimmunotherapy (RIT) is a combination of the therapeutic properties of radioisotopes and specific antibodies used to eliminate tumors. Methods: The expression of FZD10 was evaluated via immunohistochemistry using formalin-fixed paraffin blocks collected from 84 patients with cervical cancer who underwent surgery. Normal cervical from 10 patients, normal ovarian tissues from 10, uterine carcinomas from 10, and uterine sarcomas from 9 were used for comparison.Mice inoculated with the SiHa cell line, which is derived from cervical squamous cell carcinoma, were used to examine the effects of Results: The evaluation results indicated that 70 (91 %) of the cervical cancer cases expressed FZD10 more frequently than 3 (30 %), 1 (10 %), 2 (20 %), and 0 (0 %) of the normal cervix, normal ovary, uterine carcinoma, and uterine sarcoma cases, respectively. The group treated with 3.7 MBq of Conclusions: FZD10 may be an appropriate target and

Indexed as

Cervical CancerImmunotherapyRadiotherapy

Identifiers

PMID40958973
PMCPMC12433755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.