Evidence map›Paper›PMID 40958920›Full record

ArticleAdvanced biomedical research2025

Toll-Like Receptor Dysregulation in The Hospitalized COVID-19 Patients.

Zahra Kamiab, Mohammad Kazemi Arababadi, Fatemeh Bahrehmand, Gholamreza Bazmandegan, Ahmadreza Sayadi, Mitra Abbasifard

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Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zahra KamiabDepartment of Community Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mohammad Kazemi ArababadiDepartment of Laboratory Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Fatemeh BahrehmandDepartment of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Gholamreza BazmandeganPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Ahmadreza SayadiSocial Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mitra AbbasifardDepartment of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A severe pro-inflammatory feedback is the main reason for novel coronavirus (COVID-19)-related complications. Here we intended to investigate the potential involvement of toll-like receptors (TLRs)3, TLR7, TLR8, and TLR9 in the etiopathogenesis of COVID-19. Materials and Methods: mRNA expression of TLR3, TLR7, TLR8, and TLR9 were evaluated in blood samples from 30 COVID-19-infected patients and 30 healthy controls by means of real-time polymerase chain reaction (PCR) approach. Results: The mRNA expressions of TLR3 ( Conclusion: It seems that TLR3 and TLR9 are involved during COVID-19 infection and might take part in the inflammatory outcome of the patients.

Indexed as

COVID-19inflammationinnate immunitytoll-like receptor

Identifiers

PMID40958920
PMCPMC12435631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.