Evidence map›Paper›PMID 40958892›Full record

ArticleMediators of inflammation2025

Mechanistic Insights Into Celastrol's Anti-Pyroptosis Effects in Osteoarthritis via SIRT2 Upregulation.

Xiaotian Chen, Yining Song, Fan Zhang, Fangyan Hu, Zhenfei Ding, Jianzhong Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaotian ChenDepartment of Orthopaedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.ORCID https://orcid.org/0009-0006-6790-8867
Yining SongSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.ORCID https://orcid.org/0009-0007-5063-6233
Fan ZhangSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.ORCID https://orcid.org/0009-0007-5407-7942
Fangyan HuSchool of Pharmacy, Bengbu Medical University, Bengbu 233030, China.ORCID https://orcid.org/0009-0008-6292-6921
Zhenfei DingDepartment of Orthopaedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.ORCID https://orcid.org/0000-0001-5859-4604
Jianzhong GuanDepartment of Orthopaedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.ORCID https://orcid.org/0000-0001-5304-8663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

OsteoarthritisPentacyclic TriterpenesPyroptosisSirtuin 2TriterpenesAnimalsCells, CulturedChondrocytesLipopolysaccharidesMaleNLR Family, Pyrin Domain-Containing 3 ProteinRatsRats, Sprague-DawleyUp-RegulationcelastrolLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinPentacyclic TriterpenesSirt2 protein, ratSirtuin 2TriterpenescelastrolNLRP3osteoarthritispyroptosissirtuin 2

Identifiers

PMID40958892
PMCPMC12436004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.