ArticleFrontiers in oncology2025
The application of peripheral blood immune profiling in personalized treatment of locally advanced and advanced lung cancer: a nomogram approach.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Purpose: Immunotherapy has revolutionized the treatment of lung cancer, yet many patients experience limited or transient benefits. Identifying those most likely to benefit remains a critical challenge. This study aims to establish a predictive model based on peripheral blood lymphocyte subsets to evaluate treatment responses in locally advanced and advanced lung cancer patients receiving chemotherapy with or without immunotherapy. Methods: We prospectively enrolled 171 patients, peripheral blood lymphocyte subsets were analyzed pre-treatment, post-treatment, and at disease progression using flow cytometry, focusing on CD3 Results: Baseline lymphocyte profiles were closely associated with treatment responses. Elevated CD3 Conclusion: Peripheral blood lymphocyte subsets are promising non-invasive biomarkers for predicting treatment responses in locally advanced and advanced lung cancer patients, particularly with immunotherapy. The developed nomogram models enhance predictive accuracy, supporting personalized treatment decisions.
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