ArticleFrontiers in psychiatry2025
Depression-associated reductions in putaminal volume are accompanied by a shift from matrix-like to striosome-like structural connectivity.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026Article
- A diffusion MRI-based structural assessment of the striatal compartments, striosome and matrix, in Obsessive Compulsive Disorder.Research square · 2026Article
- In Humans, fMRI Reveals That Striosome-Like and Matrix-Like Striatal Voxels Are Engaged in Different Phases of Movement.Human brain mapping · 2026Article
- Hippocampal Projections to the Striatal Compartments, Striosome and Matrix, are Spatially Segregated in CA1.bioRxiv : the preprint server for biology · 2026Article
- Striosome-Like Structural Connectivity Is Reduced in the Rostral Putamen in Anxiety Disorder.Depression and anxiety · 2026Article
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Authors and funding
2 authors.
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Abstract
The striatum is among the most studied brain regions in Major Depressive Disorder (MDD) due to its involvement in reward, motivation, and executive functions. The striatum is comprised of interdigitated tissue compartments (matrix and striosome) that have distinct connectivity, pharmacology, and susceptibility to neuropsychiatric diseases. Each compartment is embedded in distinct functional networks, and functional networks that are abnormal in MDD (eg, the default mode and salience networks) selectively couple with the striosome. We hypothesized that imbalances in function between the striatal compartments could correlate with MDD. Historically, assessing compartment-specific involvement in MDD required histological staining of postmortem tissue, precluding
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