Evidence map›Paper›PMID 40958774›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Gal3-CaN-Smurf1 Complex Sequestrates FLCN-FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage.

Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role of Sigmar1 in Autophagy Regulation and Disease Therapy.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qin XiaState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Ziwan LiuState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Gaoqing FengState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Wanting XuState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
HuaHua WangState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Haihang SuState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Jiaqian LiState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Dan LiuState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Jun QuDepartment of General Surgery, Aerospace Center Hospital, Beijing, 100049, China.
Tonghui YuSchool of Physical and Mathematical Sciences, Nanyang Technological University, 639798, Singapore, Singapore.
Lei DongState Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.ORCID https://orcid.org/0000-0001-7530-7427

Funding

Beijing Municipal Natural Science Foundation QY24187Fundamental Research Funds for the Central Universities 2024CX06057,2024CX06114Hebei Natural Science Foundation C2025105003National Natural Science Foundation of China 32570906National Natural Science Foundation of China U21A20200Shandong Provincial Natural Science Foundation ZR2024MC035Shandong Provincial Natural Science Foundation ZR2024QC039
6 · The paper itself

Abstract

Smurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3-CaN-Smurf1 complex, which is critical for TFEB dephosphorylation. However, whether Smurf1 plays a role in the inhibition of mTOR-mediated TFEB phosphorylation is still unclear. TFEB phosphorylation by mTORC1 is strictly dependent on RagC/D GTPase activating protein FLCN. Here, we found that Smurf1 promotes the dissociation of RagC from TFEB upon lysosomal damage, selectively impairing TFEB phosphorylation. These findings suggest that the lysosomal damage-induced Gal3-CaN-Smurf1 complex sequesters FLCN-FNIPs to facilitate TFEB activation. This disruption of FLCN GAP function toward RagC/D impairs TFEB's lysosomal localization and phosphorylation. Notably, FLCN

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsUbiquitin-Protein LigasesHEK293 CellsHumansLysosomesPhosphorylationTransient Receptor Potential ChannelsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMCOLN1 protein, humanSMURF1 protein, humanTFEB protein, humanTransient Receptor Potential ChannelsUbiquitin-Protein Ligasesendomembrane damageFLCN‐FNIPsGal3‐CaN‐Smurf1 complexlysosomal stressTFEBubiquitylation

Identifiers

PMID40958774
PMCPMC12561182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.