Evidence map›Paper›PMID 40958651›Full record

ArticleJournal of cell science2025

Glutamate decreases oxidative stress and lipid droplet formation in astrocytes.

Luis Fernando Rubio-Atonal, Jinlan Chang, Julie Jacquemyn, Isha Ralhan, Iset Ilarraza, Maria S Ioannou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luis Fernando Rubio-AtonalDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Jinlan ChangDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Julie JacquemynDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Isha RalhanDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Iset IlarrazaDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Maria S IoannouDepartment of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.ORCID 0000-0001-6252-8626

Funding

Canada Research Chairs #2021-00027Canada Research Chairs 2021-00027CIHR 181551EMBO ALTF 120-2022Natural Sciences and Engineering Research Council of Canada 2020-04047NSERC #2020-04047University of AlbertaWomen and Children's Health Research Institute
6 · The paper itself

Abstract

Astrocytes degrade fatty acids in response to glutamate while reducing the abundance of lipid droplets. But how glutamate regulates lipid droplets in astrocytes is unclear. Here, we used primary rat astrocytes to show that glutamate decreases the amount of reactive oxygen species, which, in turn, reduces autophagy and the amount of lipids in need of storage in lipid droplets. This decrease in lipid droplets and reactive oxygen species occurs independently of glutamate import through excitatory amino acid transporters (EAATs). However, activation of AMPK, downstream of EAATs, further promotes a decrease in lipid droplets. Glutamate also increases the pool of fused mitochondria capable of maintaining enhanced fatty acid metabolism. Our work reveals how astrocytic metabolism is regulated by glutamate, which can serve to coordinate astrocyte physiology with neuronal activity.

Indexed as

AstrocytesGlutamic AcidLipid DropletsOxidative StressAnimalsAutophagyCells, CulturedMitochondriaRatsRats, Sprague-DawleyReactive Oxygen SpeciesGlutamic AcidReactive Oxygen SpeciesAstrocytesAutophagyFatty acid oxidationLipid dropletLipid peroxidationOxidative stress

Identifiers

PMID40958651
PMCPMC12539204

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.