Evidence map›Paper›PMID 40958634›Full record

ArticleCNS neuroscience & therapeutics2025

Bilirubin Alleviates Spinal Cord Injury by Enhancing SOCS3-Mediated Anti-Inflammatory Effects via Gas6-Axl Signaling.

Kun-Mao Jiang, Ya-Qi Luan, Na Shen, Xiu-Ting Qi, Liang Hu, Yu Wang, Wen-Tao Liu, Rong Wang, Tong-Tong Lin, Da-Yong Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kun-Mao JiangDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Ya-Qi LuanDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Na ShenJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Xiu-Ting QiJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Liang HuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Yu WangRehabilitation Medicine Center, The First Afliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wen-Tao LiuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.ORCID 0000-0001-8732-7927
Rong WangDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Tong-Tong LinState Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Da-Yong PengDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shangdong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Funding

National Natural Science Foundation of China 82204542National Natural Science Foundation of China 82271252Research Hospital Association of Shandong Province 2022016Scientific Research Incubation of Shandong First Medical University and Shandong Academy of Medical Sciences 202201-086
6 · The paper itself

Abstract

backgroundMany studies have emphasized the role of microglia-mediated neuroinflammation in spinal cord injury (SCI); however, effective clinical targets remain elusive. The growth arrest-specific 6 (Gas6)/Axl receptor tyrosine kinase (Axl) signaling pathway has been implicated in reducing inflammation, promoting tissue repair, and functional recovery. Here, we elucidate the importance of the Gas6-Axl signaling pathway in SCI repair and evaluate the role of bilirubin in modulating Gas6-Axl signaling after SCI.

methodsSCI mice model was used to investigate the effects of bilirubin treatment on inflammation and motor function recovery. Additionally, Gas6-deficient (Gas6

resultsGas6

conclusionsThis study underscores the importance of the Gas6-Axl-SOCS3 axis in regulating functional recovery and inflammation after SCI. Activation of the Gas6-Axl pathway, particularly when combined with bilirubin treatment, represents a promising therapeutic strategy for mitigating SCI-induced damage and improving functional outcomes. Given their central role in both the pathogenesis and resolution of SCI, bilirubin treatment emerges as a promising clinical therapeutic drug for SCI.

Indexed as

Anti-Inflammatory AgentsBilirubinIntercellular Signaling Peptides and ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSpinal Cord InjuriesSuppressor of Cytokine Signaling 3 ProteinAnimalsFemaleGrowth Arrest-Specific Protein 6MaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaRecovery of FunctionAnti-Inflammatory AgentsBilirubinGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSocs3 protein, mouseSuppressor of Cytokine Signaling 3 ProteinAxlbilirubinGas6microglianeuroinflammationspinal cord injury

Identifiers

PMID40958634
PMCPMC12441303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.