Evidence map›Paper›PMID 40958619›Full record

ReviewEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2025

Antithrombotic therapy in complex percutaneous coronary intervention.

Domenico Simone Castiello, Angelo Oliva, Giuseppe Andò, Giampaolo Niccoli, Francesco Pelliccia, Elisabetta Moscarella, Rocco Antonio Montone, Felice Gragnano, Italo Porto, Paolo Calabrò and 9 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Domenico Simone CastielloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Angelo OlivaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy and Cardio Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Giuseppe AndòDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Giampaolo NiccoliDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Francesco PellicciaDepartment of Cardiovascular Sciences, University Sapienza, Rome, Italy.
Elisabetta MoscarellaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Rocco Antonio MontoneDepartment of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Felice GragnanoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Italo PortoDepartment of Internal Medicine and Specialties, University of Genoa, Genoa, Italy.
Paolo CalabròDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Salvatore De RosaDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Carmen Anna Maria SpaccarotellaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Enrico FabrisCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Giovanni EspositoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Ciro IndolfiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Gianfranco SinagraCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Pasquale Perrone FilardiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Raffaele PiccoloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
On Behalf Of The Working Group Of Interventional Cardiology Of The Italian Society Of Cardiology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decades, percutaneous coronary intervention (PCI) has become the most common modality for myocardial revascularisation, and it is increasingly used in patients with advanced coronary artery disease. Antithrombotic therapy, including antiplatelet and anticoagulant drugs, plays a key role and should be part of the optimal revascularisation strategy in the early phase as well as in the long-term prevention of ischaemic events. An antithrombotic therapy regimen of increased intensity and/or duration may mitigate part of the ischaemic burden associated with complex PCI. However, patients undergoing complex PCI are often at increased bleeding risk, challenging, therefore, the decision-making process. In this setting, the optimal antithrombotic treatment is still a matter of debate and has become a field of intensive research. In this state-of-the-art review, we analyse the evidence related to the different approaches regarding the periprocedural and long-term antithrombotic management of patients undergoing complex PCI. Since a "one-size-fits-all" approach cannot be justified in this clinical setting, our aim is to tailor the antithrombotic strategy to each patient's profile and PCI complexity. We discuss the type and duration of antithrombotic regimens that can be selected for patients undergoing complex PCI, with a focus on prolonged dual antiplatelet therapy, P2Y

Indexed as

AnticoagulantsCoronary Artery DiseaseFibrinolytic AgentsPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsHemorrhageHumansTreatment OutcomeAnticoagulantsFibrinolytic AgentsPlatelet Aggregation Inhibitors

Identifiers

PMID40958619
PMCPMC12418109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.