Evidence map›Paper›PMID 40958459›Full record

ArticleAngewandte Chemie (International ed. in English)2025

NIR-Activatable, Sequence-Specific Metal-Nucleic Acid Scaffolds for Responsive Uncaging.

Arpit Sharma, Man Kshetri, Deepak Karna, Md Al Amin, Shirin Akter, Hanbin Mao, Yao-Rong Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arpit SharmaDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.
Man KshetriDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.
Deepak KarnaDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.
Md Al AminDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.
Shirin AkterDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.ORCID 0009-0001-0158-8091
Hanbin MaoDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.
Yao-Rong ZhengDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio, 44242, USA.ORCID 0000-0003-4605-1121

Funding

Supplemental Request for Mechanical Modulation of Cell Migrations by DNA NanoassembliesR01CA252827 · NCI · KENT STATE UNIVERSITY · PI Hanbin Mao · 2023 to 2026
$1.4M
Light-Controlled Supramolecular Platinum Complexes for Biomedical ApplicationsR15GM152919 · NIGMS · KENT STATE UNIVERSITY · PI ZHENG, YAORONG · 2024 to 2024
$434k
NCI NIH HHS R01 CA252827NIGMS NIH HHS R15 GM152919NIH HHS 1R01CA252827NIH HHS 1R15GM152919-01
6 · The paper itself

Abstract

Precise molecular activation with both analyte specificity and spatiotemporal control remains a major challenge in responsive diagnostics, targeted therapies, and the study of complex biological systems. Traditional photo-uncaging strategies offer excellent temporal resolution but suffer from limited tissue penetration and poor biological specificity, while analyte-responsive platforms provide molecular selectivity without external control. Here, we introduce sequence-responsive diagnostic uncaging-a unique approach that integrates nucleic acid recognition with near-infrared (NIR)-triggered molecular activation within a metal-nucleic acid scaffold. This platform is built upon a first-of-its-kind Pt(IV)-DNA molecular scaffold, modularly assembled via click chemistry, and integrates a Pt(IV)-caged reporter, a nucleic acid recognition domain, and an NIR antenna (e.g., IR800). Notably, DNA-mediated electron transfer (DNA-MET) provides a long-range ET pathway to direct photoreduction of the Pt(IV) centers, enabling "responsive uncaging" that occurs only upon hybridization with a fully complementary DNA or miRNA strand. Upon NIR irradiation, the duplexed nucleic acid system facilitates electron transfer from the excited antenna to Pt(IV), triggering the release of fluorescent reporters. Using two Pt(IV)-caged fluorophores (MCA and BDP), we demonstrate efficient uncaging and high sequence specificity in both solution and live cells. This platform offers a powerful and versatile photochemical tool that seamlessly bridges diagnostics and molecular activation, with broad implications for precision medicine, targeted drug delivery, and next-generation biosensing technologies.

Indexed as

Metal-Organic FrameworksDNADrug Delivery SystemsHumansMicroRNAsNucleic AcidsPlatinumDNAMetal-Organic FrameworksMicroRNAsNucleic AcidsPlatinumDNA‐mediated electron transferMolecular machinesNear infraredPlatinum(IV) complexes

Identifiers

PMID40958459
PMCPMC12582009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.