ArticleNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2026
Pilot study on the use of a multimorbidity index in patients receiving home parenteral nutrition.
Article in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHome parenteral nutrition (HPN) patients often have multiple comorbidities. A validated multimorbidity index (MMI) could help determine resource needs and risks with HPN. We evaluated MMI scoring to determine if it predicted HPN resource use and outcomes.
methodsWe performed a secondary analysis of 60 HPN patients from a previous study based on Cumulative Illness Rating Scale (CIRS) scoring. We examined three variables: PN formula changes, hospitalizations, and hospital length of stay (LOS). Density plots were produced to select a CIRS score cutoff value. Spearman correlations among the three variables of interest were computed. The data were then subjected to Wilcoxon rank sum tests and negative binomial regression models to determine if the measured variables differed significantly between the groups.
resultsIn 60 HPN patients, CIRS scores ranged from 9 to 25 with a mean ± SD of 17.0 ± 3.85. Patients with CIRS scores ≥ 17 had higher rates of the three variables than those with CIRS scores < 17 (PN formula changes = 367 vs 297, hospitalizations = 19 vs 12, and total hospital LOS days = 122 vs 100). Although these raw data did not differ significantly, negative binomial regression analysis indicated that the interaction of total hospital LOS and PN formula changes was significantly higher in patients with a CIRS score ≥ 17 than a CIRS score < 17.
conclusionCIRS data from HPN patients showed a trend wherein higher multimorbidity scores were associated with PN changes and LOS. This approach requires further study and validation.
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