ArticleVeterinary ophthalmology2026
An Ocular Manifestation of a Systemic Disease With Encephalitozoon Pogonae in a Juvenile Central Bearded Dragon (Pogona vitticeps).
Article in Veterinary ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveEncephalitozoon pogonae, a recently identified microsporidian species, has been associated with systemic infections in Central bearded dragons (Pogona vitticeps) manifesting as granulomatous inflammation and vasculitis. Despite the species similarity to Encephalitozoon cuniculi, which causes ocular, neurologic, and renal pathology in rabbits, ocular manifestations of E. pogonae in bearded dragons are underreported. This case report aims to explore the ocular manifestations of E. pogonae in a clinical case and highlight the challenges in diagnosis and treatment of microsporidial infections in reptiles. ANIMAL STUDIED: A 6-month-old male central bearded dragon with initial presentation of unilateral blepharoconjunctivitis. PROCEDURES: The patient was treated with topical ofloxacin 0.3% ophthalmic solution, systemic nonsteroidal anti-inflammatories (meloxicam), and antimicrobials (ceftazidime). Diagnostic efforts included physical and ophthalmic examination, ocular high-frequency ultrasound (48 mHz transducer), cytological examination of conjunctiva, and histopathological examination with PCR analysis confirming E. pogonae in both liver and conjunctiva.
resultsDespite treatment, the patient died from hemopericardium. Necropsy demonstrated severe granulomatous inflammation in multiple organs, including the liver, intestines, and ocular structures (conjunctiva and uveal tissue), as well as hypermature cataracts and phacoclastic uveitis, consistent with systemic microsporidiosis.
conclusionsThis case highlights the potential for an ocular manifestation of a systemic disease caused by E. pogonae, underscoring the importance of considering microsporidial infections in the differential diagnosis of refractory ocular disease in reptiles. The findings also emphasize the challenges in diagnosing and treating these infections.
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