Evidence map›Paper›PMID 40958371›Full record

Trial reportJournal of psychopharmacology (Oxford, England)2026

The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust.

Ramona L Martinez, Nina Radošić, Hanna Molla, Harriet de Wit, Sonja Lyubomirsky

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramona L MartinezDepartment of Psychology, University of California, Riverside, CA, USA.ORCID 0000-0001-9922-4327
Nina RadošićDepartment of Psychology, University of California, Riverside, CA, USA.
Hanna MollaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA.ORCID 0000-0002-7211-8994
Sonja LyubomirskyDepartment of Psychology, University of California, Riverside, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe empathogen and psychostimulant 3,4-methylenedioxymethamphetamine (MDMA) is thought to boost both subjective well-being and social connection. Although MDMA is considered to enhance social connection to a greater extent than other stimulant drugs, few studies have compared MDMA to other stimulants. In addition, previous studies have focused on social positivity effects (e.g., increased trust) for specific in-lab interaction partners without considering more generalized social positivity effects (e.g., trust in one's community).

aimsWe tested the effects of MDMA on subjective ratings of well-being and global social connection, including feelings of trust toward one's community and society. The effects of MDMA were compared to a prototypic stimulant, methamphetamine (MA).

methodsAcross two studies, we examined differences in subjective well-being and global social well-being 90 minutes after a conversation on MDMA (study 1;

resultsAfter MDMA, participants reported significantly higher global trust,

conclusionsOur findings extend previous research by demonstrating that MDMA increases feelings of trust in the social world beyond lab-specific interaction partners. These findings are consistent with user reports of generalized social well-being effects and support the idea that MDMA may have clinical value from a social psychological perspective.

Indexed as

Central Nervous System StimulantsEmpathyMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineTrustAdultEmotionsFemaleHallucinogensHumansInterpersonal RelationsMalePsychological Well-BeingYoung AdultCentral Nervous System StimulantsHallucinogensMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineinterpersonal communicationMDMAmethamphetaminesocial connectionsocial interactiontrust

Identifiers

PMID40958371
PMCPMC13490657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.