Evidence map›Paper›PMID 40958206›Full record

ArticlePrion2025

Differential pathology of P102L-associated Gerstmann-Stäussler-Scheinker disease: exclusive presence of 8-kDa protease-resistant prion protein vs. co-existence of 8-kDa and type-1 protease-resistant prion protein, with a focus on codon 129 polymorphism.

Hideko Noguchi, Motoi Yoshimura, Akihiro Watanabe, Sachiko Koyama, Naonori Sakurada, Masahiro Shijo, Takaaki Kanemaru, Keita Kai, Shinichi Aishima, Haruki Koike and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Prion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hideko NoguchiDepartment of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Motoi YoshimuraDepartment of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akihiro WatanabeDivision of Neurology, Department of Neurology, Neuro Muscular Center, National Hospital Organization, Omuta Hospital, Omuta, Japan.
Sachiko KoyamaDepartment of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Naonori SakuradaNeuropathology Center, National Hospital Organization, Omuta Hospital, Omuta, Japan.
Masahiro ShijoDepartment of Neurology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
Takaaki KanemaruDepartment of Morphology Core Unit, Kyushu University Hospital, Fukuoka, Japan.
Keita KaiDepartment of Pathology, Saga University Hospital, Saga, Japan.
Shinichi AishimaDepartment of Scientific Pathology Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Haruki KoikeDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Yoshio TsuboiDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Naokazu SasagasakoDivision of Neurology, Department of Neurology, Neuro Muscular Center, National Hospital Organization, Omuta Hospital, Omuta, Japan.
Hiroyuki HondaDepartment of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-4225-7248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gerstmann - Sträussler - Scheinker disease (GSS) is a hereditary prion disease characterized by clinicopathological heterogeneity. In Japan, the most common mutation is P102L, typically associated with prion protein (PrP) plaques, spongiform changes, and synaptic PrP deposits. Two major protease-resistant PrP (PrP

Indexed as

CodonGerstmann-Straussler-Scheinker DiseasePolymorphism, GeneticPrion ProteinsBrainFemaleHumansMiddle AgedCodonPrion ProteinsAmyloidcotton woolGerstmann–Sträussler–Scheinker diseaseprion diseasesspongiform degeneration

Identifiers

PMID40958206
PMCPMC12445514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.