Evidence map›Paper›PMID 40958117›Full record

ArticleBMC oral health2025

Assessment of volumetric changes after regenerative endodontic procedures using semiautomated and 3D U-NET automated CBCT segmentation: a retrospective cohort study.

M Baraka, N El-Kateb, M Gamal, A H Elwan, P Sharaf, L Cevidanes, M Torki, R El Backly

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PubMed Full text at PMC Publisher
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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M BarakaPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Champollion St., El Azareta, Alexandria, Egypt. marwa.baraka@alexu.edu.eg.ORCID http://orcid.org/0000-0001-7259-5515
N El-KatebEndodontics, Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Champollion St., El Azareta, Alexandria, Egypt.
M GamalDepartment of Computer and Systems Engineering. Faculty of Engineering, Alexandria University, Bab Sharqi WA Wabour Al Meyah, Al Attarin, Alexandria, Egypt.
A H ElwanPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Champollion St., El Azareta, Alexandria, Egypt.
P SharafConservative Dentistry Department, Faculty of Dentistry, Pharos University, Canal El Mahmoudia Street, Beside, Green Plaza, Alexandria, Egypt.
L CevidanesDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, 1011 N University Ave, Ann Arbor, MI, 48104, USA.
M TorkiDepartment of Computer and Systems Engineering, Faculty of Engineering, Alexandria University, Bab Sharqi WA Wabour Al Meyah, Al Attarin, Alexandria, Egypt.
R El BacklyEndodontics, Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Champollion St., El Azareta, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis retrospective cohort study evaluated volumetric changes in dental pulp and root structure of necrotic teeth after regenerative endodontic procedures (REPs) compared to contralateral counterparts (CON) using semiautomated segmentation and a 3D UNet model.

methodsData from 23 teeth with REPs and their CON were analyzed. Semiautomated segmentation was performed using ITK-SNAP and 3D Slicer CMF on scans taken before and 12 months post-treatment. Measurements included root length, volume changes (dentinal wall, intracanal calcification, and pulp) below the Biodentine plug. Automated pulpal segmentation utilized a 3D UNet model trained on 400 samples from the ToothFairy dataset, achieving a Dice Similarity Index of 0.76, Intersection over Union of 0.61, and Hausdorff distance of 2.15.

resultsREP teeth showed no significant differences in root volume or dentinal changes compared to CON. REP significantly reduced pulp volume in mature teeth (-4.86 mm3 vs. -1.34 mm3, p = 0.05), with lesser changes in immature teeth (-3.20 mm3 vs. -6.44 mm3, p = 0.12). Significant root length differences (p = 0.04) were observed between mature and immature teeth with REPs. The 3D UNet model and semi-automated method for volumetric pulp assessment showed excellent agreement (ICC = 0.92, p < 0.001). Bland–Altman plots indicated good agreement between the two methods in measuring pulpal volumetric changes.

conclusionsREPs yield comparable findings to CON in root volume and dentinal wall changes, while significantly reduced pulp volume in mature teeth compared to CON. Distinct patterns of intracanal calcification and root length changes between mature and immature teeth were identified. A deep learning model can expedite post-REP pulp volume evaluations. CLINICAL IMPLICATIONS: Understanding volumetric changes in dental pulp and root structure is vital for assessing REP success, facilitating clinical decision-making, and improving outcomes in regenerative endodontics.

Indexed as

Cone-Beam Computed TomographyDental PulpDental Pulp NecrosisImaging, Three-DimensionalRegenerative EndodonticsFemaleHumansRetrospective StudiesTooth Root3D Unet modelDeep learningRegenerative endodonticRoot length changesVolumetric dentinal changesVolumetric pulpal changes

Identifiers

PMID40958117
PMCPMC12442267

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.