Evidence map›Paper›PMID 40958068›Full record

ArticleAnnals of hematology2025

Challenges in accuracy in molecular genetic diagnosis of childhood AML: case series.

Fernanda de Oliveira Mota, Silva Regina Caminada de Toledo, Francine Tesser-Gamba, Michele Gaboardi de Carvalho Pires, Juliana Thomazini Gouveia, Indhira Dias Oliveira, Nancy da Silva Santos, Elizabete Delbuono, Bruno Nicolaz Rhein, Renata Fittipaldi da Costa Guimarães and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fernanda de Oliveira MotaPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.ORCID http://orcid.org/0000-0002-1356-2497
Silva Regina Caminada de ToledoPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Francine Tesser-GambaPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Michele Gaboardi de Carvalho PiresPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Juliana Thomazini GouveiaPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Indhira Dias OliveiraPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Nancy da Silva SantosPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Elizabete DelbuonoPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Bruno Nicolaz RheinPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil.
Renata Fittipaldi da Costa GuimarãesPediatric Oncology, Oncominas Hospital, Pouso Alegre, Minas Gerais, Brazil.
Victor Gottardello ZecchinPediatric Stem Cell Transplant, Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
Maria Lucia de Martino LeePediatric Hematology and Stem Cell Transplant, Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
Ana Virginia Lopes de SousaPediatric Oncology Institute, Grupo de Apoio ao Adolescente e à Criança com Câncer GRAACC, Federal University of São Paulo UNIFESP, Rua Botucatu 743, São Paulo, São Paulo, 04037020, Brazil. analopes@graacc.org.br.ORCID http://orcid.org/0000-0001-8479-6322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survival rate of children with Acute Myeloid Leukemia (AML) improves gradually through cooperative studies. However, the outcome depends on heterogeneous mechanisms. Comprehending the genetic background of pediatric Acute Myeloid Leukemia (AML) is the key to risk stratification. Next Generation Sequencing (NGS) technology uses target panels that may detect additional genetic subsets. The study describes the experience of using NGS for treating pediatric AML patients at an institution. Patients who showed poor outcome aberration were referred to hematopoietic stem cell transplant (HSCT). 11 patients were tested. Aberrations were found in all subjects, mainly only in the NGS panel, indicating referral to HSCT in first remission in 2 cases and helping to outline the genetic features in all cases. The availability of NGS resources has had a therapeutic impact. NGS helped outline the patients' genetic features and decision for HSCT. NGS is a valuable tool in the precision medicine era and should be widely accessible.

Indexed as

High-Throughput Nucleotide SequencingLeukemia, Myeloid, AcuteAdolescentChildChild, PreschoolFemaleHematopoietic Stem Cell TransplantationHumansInfantMaleHematopoietic stem cell transplantNext generation sequencingPediatric acute myeloid leukemiaRisk stratification

Identifiers

PMID40958068
PMCPMC12552407

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.