Evidence map›Paper›PMID 40958037›Full record

ArticleImmunologic research2025

Tyro3 upregulation is associated with muscle involvement in patients with idiopathic inflammatory myopathies.

Huan Liu, Ying Ren, Qianwei Li, Yanjun Si, Yuehong Chen, Min Dong, Geng Yin, Qibing Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan Liu *Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China.
Ying Ren *Department of Outpatient, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qianwei LiDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China.
Yanjun SiDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuehong ChenDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China.
Min DongDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China.
Geng YinDepartment of General Practice, General Practice Medical Center, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China. yingeng1975@163.com.
Qibing XieDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Number 37 Guoxue Alley in the Wuhou District, Chengdu, 610041, China. xieqibing1971@163.com.

Funding

Sichuan Provincial Science and Technology Support Program 2024YFFK0062Sichuan Provincial Science and Technology Support Program 2025ZNSFSC1748the Clinical Research Incubation Project of West China Hospital, Sichuan University 2021HXFH018
6 · The paper itself

Abstract

Tyro3, Axl, and Mer (TAM) receptors are involved in immunity and affect the progression of several autoimmune diseases. This study investigated the potential role of TAM receptors in individuals diagnosed with idiopathic inflammatory myopathies (IIM). Clinical data and serum samples were obtained from 176 patients with IIM and 50 healthy controls (HCs). The levels of soluble TAM (sTAM) receptors were measured through enzyme-linked immunosorbent assay. Additionally, Tyro3 protein expression in the muscle tissue of both patients and HCs was examined using western blot and immunohistochemistry (IHC) analyses. The levels of sTAM receptors were notably higher in IIM patients than in HCs. Specifically, serum concentrations of soluble Tyro3 (sTyro3) were markedly elevated among patients with dermatomyositis (DM) and immune-mediated necrotizing myopathy (IMNM). No significant differences were found in sTyro3 levels among IMNM patients with anti-signal recognition particle positive, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase positive, and seronegative subtypes. Further, levels of sTyro3 showed an inverse relationship with the manual muscle testing-8 score, while exhibiting a positive correlation with serum creatine kinase. Following treatment, patients with IMNM and DM exhibited reduced sTyro3 levels. Results from western blotting and IHC revealed a significant expression of Tyro3 in the necrotic muscles of patients with IMNM and DM. This study demonstrated that Tyro3 causes muscle injury in patients with IIM; therefore, it is considered a potential biomarker and therapeutic target for patients with IIM.

Indexed as

Muscle, SkeletalMyositisReceptor Protein-Tyrosine KinasesAdultAgedBiomarkersFemaleHumansMaleMiddle AgedUp-RegulationBiomarkersReceptor Protein-Tyrosine KinasesTYRO3 protein, humanIdiopathic inflammatory myopathiesMuscle injuryNecrosisTyro3

Identifiers

PMID40958037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.