Evidence map›Paper›PMID 40958034›Full record

ArticleLeukemia2025

Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission.

Xuepeng Wang, Baskar Ramdas, Ramesh Kumar, Ji Zhang, Reuben Kapur

Erratum issuedAbstract readLetter
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xuepeng WangDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. xuepwang@iu.edu.ORCID http://orcid.org/0009-0009-4349-1579
Baskar RamdasDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0009-0006-2206-5720
Ramesh KumarDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-7545-4619
Ji ZhangDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Reuben KapurDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. rkapur@iupui.edu.ORCID http://orcid.org/0000-0003-2225-1700

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Metabolic adaptation in lymphoid malignanciesR01CA244625 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHANG, JI · 2020 to 2024
$2.2M
Hypoxia's role in regulating stressed hematopoietic stem cellsR01DK139505 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Ngoc Tung Tran · 2024 to 2026
$2.0M
Regulation of hematopoietic stem cells under low oxygen tensionR01HL177669 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Ji Zhang · 2025 to 2026
$1.6M
Dual anti-leukemic and cardio protective role for ROCKR21CA263470 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN, SHI, JIANJIAN · 2022 to 2023
$404k
NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA244625NCI NIH HHS R21 CA263470NHLBI NIH HHS R01 HL177669NIDDK NIH HHS R01 DK139505NIDDK NIH HHS U54 DK106846U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK139505U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R21CA263470
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40958034
PMCPMC12531631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.