Evidence map›Paper›PMID 40957937›Full record

ReviewNature materials2025

Molecular afterglow imaging for biomedical applications.

Cheng Xu, Yan Zhang, Gaolin Liang, Kanyi Pu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheng XuSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-5838-7979
Yan ZhangNational Engineering Research Centre for Nanomedicine, College of Life Science and Technology, Hubei Key Laboratory of Bio-inorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, Wuhan, People's Republic of China. yan_zhang@hust.edu.cn.ORCID 0000-0002-8811-5552
Gaolin LiangState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China. gliang@seu.edu.cn.ORCID 0000-0002-6159-9999
Kanyi PuSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore. kypu@ntu.edu.sg.ORCID 0000-0002-8064-6009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Afterglow imaging is an emerging optical modality using agents that emit long-lasting luminescence after excitation ceases to eliminate tissue autofluorescence and improve signal-to-background ratios, achieving high imaging sensitivity and deep tissue penetration. Here we review recent advances in molecular afterglow imaging for biomedical applications, highlighting the materials and mechanisms involved in afterglow imaging modalities induced by light, ultrasound and ionizing radiation, termed photoafterglow, sonoafterglow and radioafterglow, respectively. We describe strategies to modulate the lifetime, intensity and wavelength of afterglow materials and principles for designing afterglow imaging probes that feature biomarker-activatable signal readouts and optimal biophysical properties for in vivo applications. We also highlight the applications of afterglow materials in disease diagnosis, imaging-guided therapy and in vitro diagnostics, and discuss the current challenges in the clinical translation of these technologies.

Indexed as

Molecular ImagingOptical ImagingAnimalsHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.