Evidence map›Paper›PMID 40957931›Full record

ReviewNature reviews. Neurology2025

Non-invasive brain stimulation: current and future applications in neurology.

Irena Rektorová, Monika Pupíková, Lisa Fleury, Luboš Brabenec, Friedhelm C Hummel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Combined repetitive transcranial magnetic stimulation and mirror therapy for upper limb rehabilitation in stroke survivors: A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  10. Tinnitus.Nature reviews. Disease primers · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Irena RektorováApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic. irena.rektorova@fnusa.cz.ORCID 0000-0002-5455-4573
Monika PupíkováApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Lisa FleuryDefitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Luboš BrabenecApplied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Friedhelm C HummelDefitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID 0000-0002-4746-4633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Device-based non-invasive brain stimulation (NIBS) techniques show promise for the treatment of neurological and psychiatric disorders, although inconsistencies in protocol designs and study findings can make the field difficult to navigate. In this Review, we discuss applications of NIBS for enhancing cognitive and motor function in people with various neurological diseases that are characterized by disruption of large-scale brain networks, including neurodegenerative diseases and brain lesion disorders such as stroke and traumatic brain injury. In particular, we focus on repetitive transcranial magnetic stimulation and transcranial electrical stimulation, as these techniques have been widely used in clinical settings and randomized controlled trials. We summarize and synthesize current knowledge, and highlight gaps and shortcomings in the existing research that make it difficult to draw firm conclusions, including small sample sizes, heterogeneous patient populations and variations in stimulation protocols. We believe that a rapid evolution of NIBS techniques from state-dependent, network-informed, multifocal and subcortical paradigms to individualized electric field modelling and accelerated NIBS protocols will improve the management of neurological disorders. However, realizing this potential will require us to address crucial challenges and acquire deeper mechanistic insights, with the aim of developing adaptive, biomarker-driven protocols to optimize target engagement, dosing and timing for each patient.

Indexed as

BrainNervous System DiseasesNeurologyTranscranial Direct Current StimulationTranscranial Magnetic StimulationHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.