Evidence map›Paper›PMID 40957866›Full record

ArticleThe Korean journal of pain2025

Exploring the antinociceptive activity and toxicological profile of Zn(Valp)

Jozi Godoy Figueiredo, Carla Peron, Paulo Henrique Ancilaggo, Paulo Roberto Dos Santos, Vanessa Leal Scarabelot, Leandro Tasso, Sidnei Moura

Abstract read
In one paragraph

Article in The Korean journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jozi Godoy FigueiredoLaboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0003-3659-048X
Carla PeronLaboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0002-3041-9334
Paulo Henrique AncilaggoLaboratory of Pharmacology, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0001-8217-9160
Paulo Roberto Dos SantosLaboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0002-5777-9073
Vanessa Leal ScarabelotGraduate Program in Biological Sciences, Pharmacology and Therapeutics, Institute of Basic Health Sciences, University of Federal Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-7946-5702
Leandro TassoLaboratory of Pharmacology, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0002-9986-2262
Sidnei MouraLaboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Caxias do Sul, RS, Brazil.ORCID https://orcid.org/0000-0003-1903-6735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antiepileptic drugs have shown promise in treating acute nociceptive pain. Bioisosterism is a crucial strategy in analgesic development, enabling molecular modifications that improve therapeutic efficacy and safety. This study aims to develop and evaluate new compounds based on the concept of bioisosterism, synthesizing organocomplexes derived from compounds with established analgesic properties. Methods: A novel prototype, Zn(Valp) Results: Zn(Valp) Conclusions: Zn(Valp)

Indexed as

AnalgesicsAnticonvulsantsDrug DevelopmentNociceptionOrganometallic CompoundsToxicity TestsZinc

Identifiers

PMID40957866
PMCPMC12485462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.