ArticleACS nano2025
AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism.
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Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
–field-weighted citation impact
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Who cites it
16 citing papers in PubMed.
- Bioactive lipid-derived nanoparticles for RNA delivery.Materials today (Kidlington, England) · 2026Article
- Overcoming hepatic tropism: Precision engineering of lipid nanoparticles for extrahepatic RNA delivery.Materials today. Bio · 2026Review
- Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.Inflammopharmacology · 2026Review
- New approach methodologies (NAMs) for preclinical and translational evaluation of mRNA-lipid nanoparticle (LNP) therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Review
- TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation.Nature communications · 2026Article
- Article
- Ionizable Polymeric Micelles Targeting Transferrin Receptor 1 Enhance Systemic mRNA Delivery to the Brain.Molecular pharmaceutics · 2026Article
- Status and outlook of mRNA therapeutics for viral diseases.EMBO molecular medicine · 2026Review
- Artificial intelligence-driven nano-enhanced stem cell therapy for neurodegenerative diseases: from rational design to clinical translation.Journal of nanobiotechnology · 2026Review
- Lipid Nanoparticle Development in Practice: Challenges and Collective Insights.Pharmaceutical research · 2026Review
- In vivo engineering of CAR-T cells: delivery strategies and clinical translation.Biomarker research · 2026Review
- Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence.Stem cells translational medicine · 2026Review
- Modified self-amplifying RNA mediates robust and prolonged gene expression in the mammalian brain.bioRxiv : the preprint server for biology · 2025Article
- Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
- Designing intranasal formulations for Alzheimer's disease: A material-based perspective.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
33 authors.
Mor SelaThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Gal ChenThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0001-5715-181X
Haim KadoshThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0009-0009-5190-1937
Tomer KaganDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Raneen NicolaDepartment of Biomedical Engineering, Engineering Faculty, Tel Aviv University, Tel Aviv 6997801, Israel.
Sally TurutovFaculty of Computer Sciences, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Yuval RichtmanThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Lin ZhigeFaculty of Biotechnology and Food Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Mia R Albalak MenasherovThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0002-7102-0821
Shaked KaganThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Tzur SchroederStudent at the Faculty of Medicine, The Rappaport Faculty of Medicine and Research Institute, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Patricia Mora-RaimundoThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Reaam KablanThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Egor EgorovThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Anas OdehDepartment of Genetics and Developmental Biology, The Rappaport Faculty of Medicine and Research Institute, Technion─Israel Institute of Technology, Haifa, 3200003 Israel.
Tasneem Abu-RaiyaThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Inbal IonitaCryoEM Laboratory of Soft Matter, Department of Biotechnology and Food Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Inbar FreilichCryoEM Laboratory of Soft Matter, Department of Biotechnology and Food Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Galoz KanetiThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Ibrahim KnaniThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0001-9795-6436
Yehuda AravDepartment of Applied Mathematics, Israel Institute for Biological Research, Ness-Ziona 7410001, Israel.ORCID 0000-0002-6016-634X
Yael Leichtmann-BardoogoDepartment of Biomedical Engineering, Engineering Faculty, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0003-1130-5064
Keshet TadmorSagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Jeny ShkloverThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0002-4713-5653
Tommaso PatriarchiInstitute of Pharmacology and Toxicology, University of Zürich, CH-8006 Zürich, Switzerland.ORCID 0000-0001-9351-3734
Dganit DaninoCryoEM Laboratory of Soft Matter, Department of Biotechnology and Food Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Peleg HassonDepartment of Genetics and Developmental Biology, The Rappaport Faculty of Medicine and Research Institute, Technion─Israel Institute of Technology, Haifa, 3200003 Israel.
Uri AsherySagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Amit ZeiselFaculty of Biotechnology and Food Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Ben M MaozDepartment of Biomedical Engineering, Engineering Faculty, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0002-3823-7682
Tal LavivDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0003-1460-6698
Kira RadinskyFaculty of Computer Sciences, Technion─Israel Institute of Technology, Haifa 3200003, Israel.
Avi SchroederThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion─Israel Institute of Technology, Haifa 3200003, Israel.ORCID 0000-0003-2571-5937
Funding
Serotonergic IL-1R1 and Neuropsychiatric Traits of an Alzheimer's Mouse ModelR21AG074846 · NIA · FLORIDA ATLANTIC UNIVERSITY · PI ASHERY, URI, BLAKELY, RANDY D. · 2022 to 2022
$379kNIA NIH HHS R21 AG074846
Abstract
Targeting therapeutic nanoparticles to the brain poses a challenge due to the restrictive nature of the blood-brain barrier (BBB). Here we report the development of mRNA-loaded lipid nanoparticles (LNPs) functionalized with BBB-interacting small molecules, thereby enhancing brain delivery and gene expression. Screening brain-targeted mRNA-LNPs in central nervous system (CNS)
Indexed as
Artificial IntelligenceBrainLipidsNanoparticlesNeuronsRNA, MessengerAcetylcholineAnimalsBlood-Brain BarrierHumansLiposomesMiceTissue DistributionAcetylcholineLipid NanoparticlesLipidsLiposomesRNA, MessengerArtificial IntelligenceBlood−Brain BarrierBrain TargetingCentral Nervous System (CNS)Gene DeliveryLipid NanoparticlesmRNA
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.