Evidence map›Paper›PMID 40957685›Full record

SynthesisBMJ global health2025

Efficacy and effectiveness of hand hygiene-related practices used in community settings for removal of organisms from hands: a systematic review.

Stephen P Hilton, Nick H An, Lilly A O'Brien, Jedidiah S Snyder, Hannah K Rogers, Oliver Cumming, Joanna Esteves Mills, Bruce Gordon, Matthew C Freeman, Bethany A Caruso and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephen P HiltonGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-0326-3231
Nick H AnGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0009-0001-7538-426X
Lilly A O'BrienGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0009-0004-1987-3706
Jedidiah S SnyderGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-7688-4450
Hannah K RogersWoodruff Health Sciences Center Library, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-9515-1439
Oliver CummingDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-5074-8709
Joanna Esteves MillsWater, Sanitation, Hygiene and Health Unit, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-5220-1424
Bruce GordonWater, Sanitation, Hygiene and Health Unit, World Health Organization, Geneva, Switzerland.ORCID 0000-0001-8760-9377
Matthew C FreemanGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-1517-2572
Bethany A CarusoHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-9738-9857
Marlene K WolfeGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA marlene.wolfe@emory.edu.ORCID 0000-0002-6476-0450

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundThis systematic review collected and synthesised evidence on the efficacy and effectiveness of commonly used hand hygiene materials and methods for removing or inactivating pathogens on hands in community settings. The evidence was generated to support the development of the WHO Guidelines for Hand Hygiene in Community Settings.

methodsWe searched PubMed, Web of Science, EMBASE, CINAHL, Global Health, Cochrane Library, Global Index Medicus, Scopus, PAIS Index, WHO IRIS, UN Digital Library and World Bank eLibrary, and consulted experts in March 2023 for studies published between 1 January 1980 and 29 March 2023. Eligible studies included laboratory and field studies measuring reduction in organisms on hands after washing as intended in community settings; healthcare settings were excluded. Two reviewers independently extracted data from each study; risk of bias was assessed using the Mixed Method Appraisal Tool and a laboratory-based quality assessment tool. Summary results in terms of log

resultsOf 177 studies that met inclusion criteria, the majority focused on alcohol-based hand sanitiser (111, 63%) and handwashing with soap and water (110, 62%). Most evidence (119, 67%) assessed bacterial reductions and only 7 (4%) studies addressed enveloped viruses. Across studies, there was a >2 log

conclusionsThe ability to compare efficacy across materials and methods was limited due to the focus on bacteria and soap and water and alcohol-based sanitisers. Additional evidence quantifying the impact of handwashing on viruses (especially enveloped viruses), handwashing alternatives other than alcohol-based sanitisers, drying methods and microbial water quality, as well as the effectiveness of many of these products in the field would support more evidence-based recommendations. PROSPERO REGISTRATION NUMBER: CRD42023429145.

Indexed as

HandHand DisinfectionHand HygieneHumansGlobal HealthHygienePublic HealthSystematic review

Identifiers

PMID40957685
PMCPMC12443168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.