Evidence map›Paper›PMID 40957681›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown-Séquard Syndrome.

Melissa Henwood, Junkui Shang, Qiang Li, John Moth, John Henwood, Yang Yi, Dustin Green, Ajay Pal, Joseph Sandoval, Wei Li and 5 more

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Melissa HenwoodDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Junkui ShangDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Qiang LiDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.
John MothDepartment of Anesthesiology, Houston Methodist Hospital, Houston, Texas 77030.ORCID 0000-0002-9487-8628
John HenwoodDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Yang YiDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Dustin GreenDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Ajay PalDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Joseph SandovalDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Wei LiDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Tiffany DunnDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Alfredo SandovalDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555.
Jiewen ZhangDepartment of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou 450001, China.
Subo YuanDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555 suyuan@utmb.edu bochen1@utmb.edu.
Bo ChenDepartment of Neurobiology, University of Texas Medical Branch, Galveston, Texas 77555 suyuan@utmb.edu bochen1@utmb.edu.ORCID 0000-0003-3814-2509

Funding

Supplement to Pathogenesis of HIV-associated sensory neuropathyR01NS122571 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YUAN, SUBO · 2021 to 2025
$2.1M
The role of neuro-immune interactions in PACAP induced migraineR01NS131507 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Dustin Pepper Green · 2024 to 2026
$1.4M
NINDS NIH HHS R01 NS122571NINDS NIH HHS R01 NS131507
6 · The paper itself

Abstract

Spinal cord injury (SCI) often results in permanent sensory deficits, significantly impairing the quality of life. These deficits are poorly addressed due to a lack of valid animal models with translational relevance. Here, we utilized a thoracic Level 8 lateral hemisection SCI mouse model (including both male and female mice) and applied a battery of behavioral assays requiring supraspinal transmission of sensory information. We also assessed ascending spinal circuits from the lumbar spinal cord to the brain. By 28 d post-SCI, sensory assessments revealed distinct deficits: reduced innocuous sensation in the ipsilateral hindpaw and enhanced sensation in the contralateral hindpaw. Both hindlimbs exhibited disrupted nocifensive behaviors, with chronic neuropathic dysesthesia observed only in the contralateral hindlimb. We provided anatomical evidence to elucidate the neural substrates responsible for these sensory discrepancies. This SCI mouse model mimics key features of human lateral hemisection conditions (Brown-Séquard syndrome) and offers a robust platform to explore underlying mechanisms and develop new therapeutic strategies.

Indexed as

Brown-Sequard SyndromeFunctional LateralitySensation DisordersSpinal Cord InjuriesAnimalsDisease Models, AnimalFemaleHindlimbMaleMiceMice, Inbred C57BLascending projectionsBrown–Séquard syndromesensory deficitsspinal cord injury

Identifiers

PMID40957681
PMCPMC12572921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.