ArticleStroke and vascular neurology2026
Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis.
Article in Stroke and vascular neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Natural History and Factors Influencing 90-Day Clinical Outcomes and 1-Year Recurrence of Thalamic Stroke.Brain and behavior · 2026Article
- Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis.Frontiers in aging neuroscience · 2026Article
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13 authors.
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Abstract
BACKGROUND AND
aimsCovert MRI markers of cerebral small vessel disease (CSVD) can coexist with large artery atherosclerosis. We aimed to explore whether the spatial distributions of these markers were diverse in people with or without intracranial artery stenosis (ICAS).
methodsThis cross-sectional analysis included 1206 stroke-free participants (aged 55.69±9.27, 62.94% female) with brain MRI and MR angiography from community-based Shunyi cohort. We analysed the relationships between ICAS and CSVD markers. We also compared the probability maps of lacunes, cerebral microbleeds (CMB), white matter hyperintensities (WMH) and cortex morphology at a voxel/vertex-wise level in groups with and without ICAS.
resultsICAS increased the risk of lacunes by 2.99-fold (95% CI 1.99 to 4.50, p<0.001), lacunes ≥3 by 5.32 times (95% CI 2.76 to 10.28, p<0.001), correlated with WMH volume (β=0.332, SE=0.059, p<0.001), WMH Fazekas scores ≥5 (OR 4.50, 95% CI 2.44 to 8.29, p<0.001) and brain parenchymal fraction (β=-0.012, SE=0.002, p<0.001), but not with CMB. ICAS is associated with lacunes in the corresponding blood supply area. Lacunes that coexist with ICAS were prone in basal ganglia, while the lacunes without ICAS appeared in centrum semiovale more often. WMH with ICAS was prone to present in deep white matter involving the bilateral pyramidal tracts and superior thalamic radiation. People with ICAS were susceptible to worse cortical atrophy of right superior frontal and left rostral anterior cingulate. No obvious distributional differences were found for CMB between the two groups.
conclusionsSince ICAS may be involved in the upstream pathogenesis of lacunes, white matter lesions and cortical atrophy, the impact of ICAS should not be ignored when evaluating MRI markers of CSVD.
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