Evidence map›Paper›PMID 40957650›Full record

ArticleLife science alliance2025

CTPS2 regulates CTP synthetase activity by interacting with CTPS1.

Norbert Minet, Benoît Heid-Picard, Vanessa Masson, Damarys Loew, Emmanuel Martin, Sylvain Latour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Norbert MinetLaboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Institut Imagine, Paris, France norbert.minet@gmail.com.ORCID 0000-0003-3570-4166
Benoît Heid-PicardLaboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Institut Imagine, Paris, France.ORCID 0000-0002-2745-4120
Vanessa MassonInstitut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.
Damarys LoewInstitut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.ORCID 0000-0002-9111-8842
Emmanuel MartinLaboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Institut Imagine, Paris, France.ORCID 0000-0003-4211-7373
Sylvain LatourLaboratory of Lymphocyte Activation and Susceptibility to EBV infection, Inserm UMR 1163, Institut Imagine, Paris, France sylvain.latour@inserm.fr.ORCID 0000-0001-8238-4391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CTP synthetases (CTPS) 1 and 2 are responsible for intracellular de novo production of the CTP nucleotide required for DNA replication and cell proliferation. CTPS1 and CTPS2 are co-expressed in most of tissues and share a high structural homology. They form homotetramers that are enzymatically active and aggregate into large intracellular storage filament-like structures termed as cytoophidia. Herein, we found that CTPS1 and CTPS2 co-localized in cytoophidia when co-expressed and CTPS2-containing filaments are dependent on CTPS1 expression. Cytoophidia were not necessary for proliferation because CTPS1

Indexed as

Carbon-Nitrogen LigasesCell ProliferationHEK293 CellsHumansProtein BindingCarbon-Nitrogen LigasesCTP synthetase

Identifiers

PMID40957650
PMCPMC12442307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.