Evidence map›Paper›PMID 40957579›Full record

ArticleNature2025

Delta-type glutamate receptors are ligand-gated ion channels.

Haobo Wang, Fairine Ahmed, Jeffrey Khau, Anish Kumar Mondal, Edward C Twomey

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. GluDs are ionotropic dopamine receptors tuned by G-proteins.bioRxiv : the preprint server for biology · 2026
    Article
  5. Molecular basis for ligand-gating of the human GluD1 receptor.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease.The European journal of neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haobo WangDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0003-3902-8326
Fairine AhmedDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeffrey KhauDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-3337-0907
Anish Kumar MondalDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Edward C TwomeyDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Twomey@jhmi.edu.ORCID 0000-0002-1855-1586

Funding

Dynamics Of Ligand Gated Ion ChannelsR35GM122528 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Vasanthi Jayaraman · 2017 to 2026
$6.2M
Ligand Gated Ion Channels Across Time and SpaceR35GM154904 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Edward C Twomey · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM122528NIGMS NIH HHS R35 GM154904
6 · The paper itself

Abstract

Delta-type ionotropic glutamate receptors (iGluRs, also known as GluDs) are members of the iGluR ligand-gated ion channel family, yet their function remains unknown

Indexed as

Ion Channel GatingLigand-Gated Ion ChannelsAnimalsCryoelectron Microscopygamma-Aminobutyric AcidHEK293 CellsHumansLigandsModels, MolecularPoint MutationProtein DomainsReceptors, GlutamateTemperaturegamma-Aminobutyric Acidglutamate receptor delta 2Ligand-Gated Ion ChannelsLigandsReceptors, Glutamate

Identifiers

PMID40957579
PMCPMC12520249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.