ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2026
Influence of Microbubble Properties and Carrier Frequency on Ultrasound Cavitation-Induced Flow Augmentation.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Ultrasound Cavitation of Microbubbles Augments Limb Perfusion and Promotes Ulcer Healing in Chronic Limb-Threatening Ischemia.JACC. Cardiovascular imaging · 2026Trial
- Musculoskeletal ultrasound-guided cellular therapy: Current applications and future directions in skeletal muscle regeneration.Iranian journal of basic medical sciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCavitation of microbubble (MB) contrast agents produces shear-mediated vasodilation and an increase in tissue perfusion. These effects are mediated through endothelial and erythrocyte shear-sensitive pathways. Our aim was to determine whether augmentation of tissue perfusion produced by cavitation is influenced by the deformability of MBs, MB charge-mediated interaction with vascular cells, or ultrasound (US) frequency, which affects MB resonance.
methodsIn mice, highly deformable lipid-stabilized decafluorobutane MBs with neutral or cationic charge, as well as less-deformable MBs (Sonazoid), were administered intravenously during proximal hind limb US (1.3 MHz, mechanical index = 1.3) for 10 minutes. In separate experiments, high-frequency US (7.0 MHz) was compared to low-frequency US. Conditional variables were compared using quantitative contrast-enhanced US perfusion imaging, and bioluminescence assays of shear-mediated adenosine triphosphate release. Beam spatial characteristics and passive cavitation detection response for each MB agent were assessed by calibrated hydrophone.
resultsPassive cavitation detection confirmed intended differences in MB deformability. Cavitation at 1.3 MHz increased perfusion in the US-exposed limb by 6- to 8-fold for highly deformable MBs. There were no differences according to MB charge despite evidence for interaction with vascular endothelial cells on intravital microscopy. Cavitation-mediated flow augmentation was lower (4-fold) for less-deformable MBs (P < .05 vs other agents). Flow augmentation was attributable to increases in microvascular flux rate (β-value). Despite producing less flow augmentation, cavitation with the less-deformable MBs produced equivalent endothelial adenosine triphosphate release. Using high-frequency US for cavitation resulted in a 60% to 70% loss of flow augmentation response.
conclusionsFactors that affect MB resonance such as US frequency and MB deformability influence the degree of flow augmentation achieved by MB cavitation. Alteration of MB charge that enhances interaction with the endothelial cells does not influence cavitation-mediated flow augmentation.
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