Evidence map›Paper›PMID 40957081›Full record

ArticleJournal of medicinal chemistry2025

Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation.

Esra Malkawi, Anish Parmar, Sanjit Das, Enas Newire, Charlotte M Jones, Kate A Morrison, Milandip Karak, Frédéric Blanc, Nicholas Harper, Rajamani Lakshminarayanan and 8 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Lipid II unlocked: strategies for obtaining a major antibiotic target.Chemical communications (Cambridge, England) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Esra MalkawiAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Anish ParmarAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Sanjit DasAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Enas NewireAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.ORCID 0000-0002-4023-8107
Charlotte M JonesAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Kate A MorrisonDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Milandip KarakSchool of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, U.K.ORCID 0000-0001-9998-5994
Frédéric BlancDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Nicholas HarperAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Rajamani LakshminarayananSingapore Eye Research Institute, The Academia, Discovery Tower Level 6, 20 College Road, Singapore, 169857, Singapore.
Zhi Sheng PohLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, 308232, Singapore.
Navin K VermaLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, 308232, Singapore.ORCID 0000-0002-5940-6633
Jennifer UnsworthAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Dallas E HughesNovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, United States.ORCID 0009-0008-5970-3858
Losee Lucy LingNovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, United States.
Stephen A CochraneSchool of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, U.K.ORCID 0000-0002-6239-6915
William HopeAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.
Ishwar SinghAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, William Henry Duncan Building, University of Liverpool, Liverpool L7 8TX, U.K.ORCID 0000-0001-7822-1063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing spread of multidrug-resistant (MDR) bacteria demands antibiotics that combine potent activity with scalable synthesis. Novo29 (clovibactin) is promising but suffers from low yield (1%), dependence on costly and noncommercial d-hydroxy-asparagine (d-Hyn

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial Agents

Identifiers

PMID40957081
PMCPMC12481569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.