Evidence map›Paper›PMID 40956999›Full record

ArticleDiabetes care2025

Risk Factors and Consequences of Lapses in Proliferative Diabetic Retinopathy Care in a National Cohort.

Serina S Applebaum, Yanhong Deng, Julia J Fu, Michael Kane, Kristen H Nwanyanwu, Sight Outcomes Research Collaborative (SOURCE) Consortium

Abstract read
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Serina S ApplebaumDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-9062-6178
Yanhong DengYale Center for Analytical Sciences, New Haven, CT.
Julia J FuDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
Michael KaneDepartment of Biostatistics, Yale School of Public Health, New Haven, CT.
Kristen H NwanyanwuDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.ORCID 0000-0003-1146-7733
Sight Outcomes Research Collaborative (SOURCE) Consortium

Funding

Short Term Research Training: Students in Health Professional SchoolsT35DK104689 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY, Sarwat I Chaudhry · 2015 to 2026
$2.6M
Undiagnosed Diabetic Retinopathy: Using Participatory Science to Design an Intervention for Patients at High-Risk for BlindnessK23EY030530 · NEI · YALE UNIVERSITY · PI NWANYANWU, KRISTEN · 2019 to 2023
$1.3M
NEI NIH HHS K23 EY030530NEI NIH HHS K23 EY030530-01NIDDK NIH HHS T35 DK104689Research to Prevent Blindness (RPB), IncRichard K. Gershon Endowed Medical Student Research Fellowship
6 · The paper itself

Abstract

objectiveTo identify prevalence, risk factors, and visual outcomes associated with occurrence and duration of lapses in proliferative diabetic retinopathy (PDR) care. RESEARCH DESIGN AND

methodsThis was a retrospective national cohort study (2008-2023) of adults with PDR and ≥6 months of follow-up who were participating in the Sight Outcomes Research Collaborative. We used multivariable regressions to assess factors associated with lapse occurrence and duration, and compared post-lapse visual acuity by lapse duration.

resultsAmong 15,211 individuals, 71.8% experienced a lapse in care; 14.2% of the lapses lasted >24 months. Lapses were more common among non-Hispanic Black, younger, and individuals with disability, and less common in those with poor vision or prior PDR treatment. Older age and PDR treatment predicted shorter lapses, and residence in distressed areas predicted longer lapses. Visual acuity worsened after lapses, with greater declines after longer lapses.

conclusionsProlonged lapses in PDR care are common, disproportionately affect vulnerable groups, and are associated with persistent vision loss.

Indexed as

Diabetic RetinopathyAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsVisual Acuity

Identifiers

PMID40956999
PMCPMC12583386

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.