ArticleAging and disease2025
Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model.
Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ischemic stroke triggers brain-wide synaptic remodeling within four hours.PLoS biology · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological impact of fever on the brain remains poorly understood. Here, we demonstrate that temperature increases by yeast injection in rats (N=9) and by whole-body hyperthermia in mice (N=7) triggers structural synaptic enhancement in the prefrontal cortex through a mechanism involving AMPA-type glutamate receptors and protein translation (N=6). Repeated pyrexia induction in juvenile rats (N=9) results in synaptic strengthening that persists into adulthood, mitigating learning deficits and synaptic loss in a D-galactose model of accelerated aging (N=9-11). Our results show how common environmental conditions may shape brain function in the long-term via synaptic plasticity, warranting further exploration of thermal treatment for cognitive protection in aging.
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Registered trials
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