Evidence map›Paper›PMID 40956896›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

DNA-utilization loci enable exogenous DNA metabolism in gut Bacteroidales.

Deepti Sharan, Agnieszka Nurek, Joshua Stemczynski, Kristof Turan, Alexander S Little, Michael J Coyne, Mary McMillin, Ashley M Sidebottom, Laurie E Comstock, Samuel H Light

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deepti Sharan *Biological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.
Agnieszka Nurek *Biological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0009-0007-4468-0449
Joshua StemczynskiBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.
Kristof TuranBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.
Alexander S LittleBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0009-0008-5716-2760
Michael J CoyneBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0009-0007-8456-213X
Mary McMillinBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.
Ashley M SidebottomBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0000-0002-8670-9090
Laurie E ComstockBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0009-0002-6368-8351
Samuel H LightBiological Sciences Division, Duchossois Family Institute, University of Chicago, Chicago 60637, IL.ORCID 0000-0002-8074-1348

Funding

Ecological niche assignment in the gut microbiome on an ecosystem-level scaleR35GM146969 · NIGMS · UNIVERSITY OF CHICAGO · PI Samuel Light · 2022 to 2026
$2.1M
HHS | National Institutes of Health (NIH) R35GM146969Kinship Foundation (The Kinship Foundation) Searle Scholars ProgramNIGMS NIH HHS R35 GM146969
6 · The paper itself

Abstract

The human gut microbiome plays a central role in nutrient metabolism, yet the fate of exogenous nucleic acids within this ecosystem remains poorly understood. Here, we show that multiple Bacteroidales species efficiently metabolize exogenous DNA, with

Indexed as

Bacteroides thetaiotaomicronBacteroidetesDNADNA, BacterialGastrointestinal MicrobiomeAnimalsBacterial ProteinsGerm-Free LifeHumansMiceUracilBacterial ProteinsDNADNA, BacterialUracilgut microbiomenucleic acid metabolismnucleobases

Identifiers

PMID40956896
PMCPMC12478041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.