Evidence map›Paper›PMID 40956885›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA.

Abdel Abdellaoui, Laura W Wesseldijk, Scott D Gordon, Joëlle A Pasman, Dirk J A Smit, Renáta Androvičová, Nicholas G Martin, Fredrik Ullén, Miriam A Mosing, Brendan P Zietsch and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Life without sex: Lack of desire or traumatic retire?Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Science and sensitivity in the study of not having sex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Abdel Abdellaoui *Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.ORCID 0000-0003-1088-6784
Laura W Wesseldijk *Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.ORCID 0000-0002-9900-0371
Scott D GordonGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.ORCID 0000-0001-7623-328X
Joëlle A PasmanDepartment of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Dirk J A SmitDepartment of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Renáta AndrovičováDepartment of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Nicholas G MartinGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Fredrik UllénDepartment of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt am Main 60322, Germany.
Miriam A MosingDepartment of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt am Main 60322, Germany.
Brendan P Zietsch *Centre for Psychology and Evolution, School of Psychology, University of Queensland, Queensland 4072, Australia.ORCID 0000-0003-0274-6140
Karin J H Verweij *Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.ORCID 0000-0001-9868-7821

Funding

The Amsterdam UMC Fellowship N/A
6 · The paper itself

Abstract

Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We investigated phenotypic and genetic correlates of never having had sex in ~400,000 UK residents aged 39 to 73 and ~13,500 Australian residents aged 18 to 89. The strongest associations revealed that sexless individuals were more educated, less likely to use alcohol and smoke, more nervous, lonelier, and unhappier. Sexlessness was more strongly associated with physical characteristics (e.g., upper body strength) in men than in women. Sexless men tended to live in regions with fewer women, and sexlessness was more prevalent in regions with more income inequality. Common genetic variants explained 17% (SE = 4%) and 14% (SE = 3%) of variation in sexlessness in men and women, with a genetic correlation between sexes of 0.56 (SE = 0.17). Polygenic scores predicted a range of related outcomes in the Australian dataset. Our findings uncover multifaceted correlates of human intimacy and raise important lines of enquiry in the evolutionary and social sciences.

Indexed as

CognitionDNAPersonalitySexual BehaviorAdolescentAdultAgedAged, 80 and overAustraliaFemaleHumansMaleMiddle AgedUnited KingdomYoung AdultDNAevolutiongeneticssexlessnesssocioecology

Identifiers

PMID40956885
PMCPMC12478097

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.